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Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Ribonucleotide reductase catalyzes a crucial step in de novo DNA synthesis and is allosterically controlled by relative levels of dNTPs to maintain a balanced pool of deoxynucleoside triphosphates in the cell. In eukaryotes, the enzyme comprises a heterooligomer of α(2) and β(2) subunits. The α subu...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1389704/ https://ncbi.nlm.nih.gov/pubmed/16537479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600443103 |
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