Inhibition of GLI1 gene activation by Patched1

Patched1 (PTCH1) is a human tumour suppressor that acts as an HH (Hedgehog) receptor protein and is important for embryonic patterning. PTCH1 mediates its effects through SMO (Smoothened) and represses the expression of HH target genes such as the transcription factor GLI1 (glioma 1) as well as PTCH...

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Autors principals: Rahnama, Fahimeh, Shimokawa, Takashi, Lauth, Matthias, Finta, Csaba, Kogerman, Priit, Teglund, Stephan, Toftgård, Rune, Zaphiropoulos, Peter G.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1385998/
https://ncbi.nlm.nih.gov/pubmed/16229683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050941
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