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Distinct roles of PTCH2 splice variants in Hedgehog signalling.

The human PTCH2 gene is highly similar to PTCH1, a tumour suppressor gene frequently mutated in basal cell carcinoma and several other tumour types. PTCH1 is a transmembrane protein believed to inhibit another transmembrane protein SMO (Smoothened), which mediates HH (Hedgehog) signalling. In this s...

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Bibliografische gegevens
Hoofdauteurs: Rahnama, Fahimeh, Toftgård, Rune, Zaphiropoulos, Peter G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2004
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223965/
https://ncbi.nlm.nih.gov/pubmed/14613484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031200
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