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Distinct roles of PTCH2 splice variants in Hedgehog signalling.
The human PTCH2 gene is highly similar to PTCH1, a tumour suppressor gene frequently mutated in basal cell carcinoma and several other tumour types. PTCH1 is a transmembrane protein believed to inhibit another transmembrane protein SMO (Smoothened), which mediates HH (Hedgehog) signalling. In this s...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1223965/ https://ncbi.nlm.nih.gov/pubmed/14613484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031200 |
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