Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning

Hedgehog (HH) signaling is essential for vertebrate and invertebrate embryogenesis. In Drosophila, feedback upregulation of the HH receptor Patched (PTC; PTCH in vertebrates), is required to restrict HH signaling during development. By contrast, PTCH1 upregulation is dispensable for early HH-depende...

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Detalhes bibliográficos
Main Authors: Holtz, Alexander M., Peterson, Kevin A., Nishi, Yuichi, Morin, Steves, Song, Jane Y., Charron, Frédéric, McMahon, Andrew P., Allen, Benjamin L.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2013
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737722/
https://ncbi.nlm.nih.gov/pubmed/23900540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.095083
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