Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation

Hedgehog (Hh) proteins regulate important developmental processes including cell proliferation and differentiation. While Patched acts as the main Hh receptor, in Drosophila, Hh signaling absolutely requires the additional Hh-binding proteins Ihog and Boi. Here we show that, unexpectedly, cerebellar...

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Detalhes bibliográficos
Main Authors: Izzi, Luisa, Lévesque, Martin, Morin, Steves, Laniel, Dominique, Wilkes, Brian C., Mille, Frédéric, Krauss, Robert S., McMahon, Andrew P., Allen, Benjamin L., Charron, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432913/
https://ncbi.nlm.nih.gov/pubmed/21664577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.04.017
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