Overlapping roles and collective requirement for the co-receptors Gas1, Cdo and Boc in Shh pathway function

Secreted Hedgehog (Hh) ligands signal through the canonical receptor Patched (Ptch1). However, recent studies implicate three additional Hh-binding, cell surface proteins, Gas1, Cdo and Boc, as putative co-receptors for Hh ligands. A central question is to what degree these co-receptors function sim...

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Main Authors: Allen, Benjamin L., Song, Jane Y., Izzi, Luisa, Althaus, Irene W., Kang, Jong-Sun, Charron, Frédéric, Krauss, Robert S., McMahon, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121104/
https://ncbi.nlm.nih.gov/pubmed/21664576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.04.018
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