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Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function
Vertebrate Hedgehog (HH) signaling is controlled by several ligand-binding antagonists including Patched-1 (PTCH1), PTCH2, and HH-interacting protein 1 (HHIP1), whose collective action is essential for proper HH pathway activity. However, the molecular mechanisms used by these inhibitors remain poor...
Guardat en:
| Publicat a: | J Cell Biol |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4460154/ https://ncbi.nlm.nih.gov/pubmed/26056142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201411024 |
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