Heparan Sulfate Microarray Reveals That Heparan Sulfate–Protein Binding Exhibits Different Ligand Requirements

Heparan sulfates (HS) are linear sulfated polysaccharides that modulate a wide range of physiological and disease-processes. Variations in HS epimerization and sulfation provide enormous structural diversity, which is believed to underpin protein binding and regulatory properties. The ligand require...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Zong, Chengli, Venot, Andre, Li, Xiuru, Lu, Weigang, Xiao, Wenyuan, Wilkes, Jo-Setti L., Salanga, Catherina L., Handel, Tracy M., Wang, Lianchun, Wolfert, Margreet A., Boons, Geert-Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588662/
https://ncbi.nlm.nih.gov/pubmed/28651046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01399
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