The 3-O-sulfation of heparan sulfate modulates protein binding and lyase degradation

Humans express seven heparan sulfate (HS) 3-O-sulfotransferases that differ in substrate specificity and tissue expression. Although genetic studies have indicated that 3-O-sulfated HS modulates many biological processes, ligand requirements for proteins engaging with HS modified by 3-O-sulfate (3-O...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Chopra, Pradeep, Joshi, Apoorva, Wu, Jiandong, Lu, Weigang, Yadavalli, Tejabhiram, Wolfert, Margreet A., Shukla, Deepak, Zaia, Joseph, Boons, Geert-Jan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826381/
https://ncbi.nlm.nih.gov/pubmed/33441484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012935118
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