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De Novo Sequencing of Complex Mixtures of Heparan Sulfate Oligosaccharides
Here, we describe the first sequencing method of a complex mixture of heparan sulfate tetrasaccharides by LC-MS/MS. Heparin and heparan sulfate (HS) are linear polysaccharides that are modified in a complex manner by N- and O-sulfation, N-acetylation, and epimerization of the uronic acid. Heparin an...
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| Publicado no: | Anal Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5068567/ https://ncbi.nlm.nih.gov/pubmed/27087275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b00519 |
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