Controlled Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides

A chemoenzymatic approach has been developed for the preparation of diverse libraries of heparan sulfate (HS) oligosaccharides. It employs chemically synthesized oligosaccharides having a chemical entity at a GlcN residue, which in unanticipated manners influences the site of modification by NST, C5...

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Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Lu, Weigang, Zong, Chengli, Chopra, Pradeep, Pepi, Lauren E., Xu, Yongmei, Amster, I. Jonathan, Liu, Jian, Boons, Geert-Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5996245/
https://ncbi.nlm.nih.gov/pubmed/29512241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201800387
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