An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

The Hedgehog signaling pathway is part of the ancient developmental-evolutionary animal toolkit. Frequently co-opted to pattern new structures, the pathway is conserved among eumetazoans yet flexible and pleiotropic in its effects. The Hedgehog receptor, Patched, is transcriptionally activated by He...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lorberbaum, David S, Ramos, Andrea I, Peterson, Kevin A, Carpenter, Brandon S, Parker, David S, De, Sandip, Hillers, Lauren E, Blake, Victoria M, Nishi, Yuichi, McFarlane, Matthew R, Chiang, Ason CY, Kassis, Judith A, Allen, Benjamin L, McMahon, Andrew P, Barolo, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Developmental Biology and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887206/
https://ncbi.nlm.nih.gov/pubmed/27146892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13550
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