An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

The Hedgehog signaling pathway is part of the ancient developmental-evolutionary animal toolkit. Frequently co-opted to pattern new structures, the pathway is conserved among eumetazoans yet flexible and pleiotropic in its effects. The Hedgehog receptor, Patched, is transcriptionally activated by He...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Lorberbaum, David S, Ramos, Andrea I, Peterson, Kevin A, Carpenter, Brandon S, Parker, David S, De, Sandip, Hillers, Lauren E, Blake, Victoria M, Nishi, Yuichi, McFarlane, Matthew R, Chiang, Ason CY, Kassis, Judith A, Allen, Benjamin L, McMahon, Andrew P, Barolo, Scott
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2016
Onderwerpen:
Developmental Biology and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887206/
https://ncbi.nlm.nih.gov/pubmed/27146892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13550
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