Llwytho...
Structural basis of sterol recognition by human hedgehog receptor PTCH1
Hedgehog signaling is central in embryonic development and tissue regeneration. Disruption of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, Sonic hedgehog (ShhN) to its receptor Patched (PTCH1) activates the signaling pathway. Here, we describe a 3.4-Å cryo-EM...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Sci Adv |
|---|---|
| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Association for the Advancement of Science
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6750913/ https://ncbi.nlm.nih.gov/pubmed/31555730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw6490 |
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