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Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme

Although general mechanisms of RNA folding and catalysis have been elucidated, little is known about how ribozymes achieve structural stability at high temperature. A previous in vitro evolution experiment identified a small number of mutations that significantly increase the thermostability of the...

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Detalhes bibliográficos
Main Authors: GUO, FENG, GOODING, ANNE R., CECH, THOMAS R.
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2006 by RNA Society 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383578/
https://ncbi.nlm.nih.gov/pubmed/16431981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2198206
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