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Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme
Although general mechanisms of RNA folding and catalysis have been elucidated, little is known about how ribozymes achieve structural stability at high temperature. A previous in vitro evolution experiment identified a small number of mutations that significantly increase the thermostability of the...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Copyright 2006 by RNA Society
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1383578/ https://ncbi.nlm.nih.gov/pubmed/16431981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2198206 |
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