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A role for the exosome in the in vivo degradation of unstable mRNAs
In mammals, the mRNAs encoding many proteins involved in inflammation bear destabilizing AU-rich elements (AREs) in the 3′-untranslated region. The exosome, a complex of 3′ → 5′ exonucleases, is rate limiting in the destruction of such mRNAs in a mammalian in vitro system, but a role in vivo has not...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Copyright 2003 by RNA Society
2003
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370503/ https://ncbi.nlm.nih.gov/pubmed/14624005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5940703 |
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