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A role for the exosome in the in vivo degradation of unstable mRNAs
In mammals, the mRNAs encoding many proteins involved in inflammation bear destabilizing AU-rich elements (AREs) in the 3′-untranslated region. The exosome, a complex of 3′ → 5′ exonucleases, is rate limiting in the destruction of such mRNAs in a mammalian in vitro system, but a role in vivo has not...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
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Copyright 2003 by RNA Society
2003
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370503/ https://ncbi.nlm.nih.gov/pubmed/14624005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5940703 |
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