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Different nuclease requirements for exosome-mediated degradation of normal and nonstop mRNAs
Two general pathways of mRNA decay have been characterized in yeast. In one pathway, the mRNA is degraded by the cytoplasmic form of the exosome. The exosome has both 3′ to 5′ exoribonuclease and endoribonuclease activity, and the available evidence suggests that the exonuclease activity is required...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3038778/ https://ncbi.nlm.nih.gov/pubmed/21262801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013180108 |
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