The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

HeLa cytoplasmic extracts contain both 3′–5′ and 5′–3′ exonuclease activities that may play important roles in mRNA decay. Using an in vitro RNA deadenylation/decay assay, mRNA decay intermediates were trapped using phosphothioate-modified RNAs. These data indicate that 3′–5′ exonucleolytic decay is...

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Bibliographic Details
Main Authors:	Mukherjee, Devi, Gao, Min, O’Connor, J.Patrick, Raijmakers, Reinout, Pruijn, Ger, Lutz, Carol S., Wilusz, Jeffrey
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2002
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC125812/ https://ncbi.nlm.nih.gov/pubmed/11782436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.1.165
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The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

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