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The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements
HeLa cytoplasmic extracts contain both 3′–5′ and 5′–3′ exonuclease activities that may play important roles in mRNA decay. Using an in vitro RNA deadenylation/decay assay, mRNA decay intermediates were trapped using phosphothioate-modified RNAs. These data indicate that 3′–5′ exonucleolytic decay is...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125812/ https://ncbi.nlm.nih.gov/pubmed/11782436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.1.165 |
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