The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

HeLa cytoplasmic extracts contain both 3′–5′ and 5′–3′ exonuclease activities that may play important roles in mRNA decay. Using an in vitro RNA deadenylation/decay assay, mRNA decay intermediates were trapped using phosphothioate-modified RNAs. These data indicate that 3′–5′ exonucleolytic decay is...

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Publicat a:	EMBO J
Autors principals:	Mukherjee, Devi, Gao, Min, O’Connor, J.Patrick, Raijmakers, Reinout, Pruijn, Ger, Lutz, Carol S., Wilusz, Jeffrey
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2002
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782436/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.1.165
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