The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

HeLa cytoplasmic extracts contain both 3′–5′ and 5′–3′ exonuclease activities that may play important roles in mRNA decay. Using an in vitro RNA deadenylation/decay assay, mRNA decay intermediates were trapped using phosphothioate-modified RNAs. These data indicate that 3′–5′ exonucleolytic decay is...

Disgrifiad llawn

Manylion Llyfryddiaeth

Cyhoeddwyd yn:	EMBO J
Prif Awduron:	Mukherjee, Devi, Gao, Min, O’Connor, J.Patrick, Raijmakers, Reinout, Pruijn, Ger, Lutz, Carol S., Wilusz, Jeffrey
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Publishing Group 2002
Pynciau:	Article
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782436/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.1.165
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!