The role of deadenylation in the degradation of unstable mRNAs in trypanosomes

Removal of the poly(A) tail is the first step in the degradation of many eukaryotic mRNAs. In metazoans and yeast, the Ccr4/Caf1/Not complex has the predominant deadenylase activity, while the Pan2/Pan3 complex may trim poly(A) tails to the correct size, or initiate deadenylation. In trypanosomes, t...

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Bibliographic Details
Main Authors: Schwede, Angela, Manful, Theresa, Jha, Bhaskar Anand, Helbig, Claudia, Bercovich, Natalia, Stewart, Mhairi, Clayton, Christine
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760810/
https://ncbi.nlm.nih.gov/pubmed/19596809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp571
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