Polycistronic trypanosome mRNAs are a target for the exosome

Eukaryotic cells have several mRNA quality control checkpoints to avoid the production of aberrant proteins. Intron-containing mRNAs are actively degraded by the nuclear exosome, prevented from nuclear exit and, if these systems fail, degraded by the cytoplasmic NMD machinery. Trypanosomes have only...

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Bibliografiske detaljer
Udgivet i:Mol Biochem Parasitol
Main Authors: Kramer, Susanne, Piper, Sophie, Estevez, Antonio, Carrington, Mark
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier/North-Holland Biomedical Press 2016
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850246/
https://ncbi.nlm.nih.gov/pubmed/26946399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2016.02.009
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