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Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-κB

The nuclear function of the heterodimeric NF-κB transcription factor is regulated in part through reversible acetylation of its RelA subunit. We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, 221 and 3...

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Autori principali: Chen, Lin-feng, Mu, Yajun, Greene, Warner C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC136963/
https://ncbi.nlm.nih.gov/pubmed/12456660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf660
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