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Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA
Acetylation of the RelA subunit of NF-κB at lysine-310 regulates the transcriptional activation of NF-κB target genes and contributes to maintaining constitutively active NF-κB in tumors. Bromodomain-containing factor Brd4 has been shown to bind to acetylated lysine-310 and to regulate the transcrip...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3913736/ https://ncbi.nlm.nih.gov/pubmed/23686307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.179 |
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