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Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA

Acetylation of the RelA subunit of NF-κB, especially at lysine-310, is critical for the transcriptional activation of NF-κB and the expression of inflammatory genes. In this study, we demonstrate that bromodomains of Brd4 bind to acetylated lysine-310. Brd4 enhances transcriptional activation of NF-...

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Sonraí Bibleagrafaíochta
Main Authors: Huang, Bo, Yang, Xiao-Dong, Zhou, Ming-Ming, Ozato, Keiko, Chen, Lin-Feng
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643823/
https://ncbi.nlm.nih.gov/pubmed/19103749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01365-08
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