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Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA
Acetylation of the RelA subunit of NF-κB, especially at lysine-310, is critical for the transcriptional activation of NF-κB and the expression of inflammatory genes. In this study, we demonstrate that bromodomains of Brd4 bind to acetylated lysine-310. Brd4 enhances transcriptional activation of NF-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643823/ https://ncbi.nlm.nih.gov/pubmed/19103749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01365-08 |
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