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Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

Acetylation of the RelA subunit of NF-κB at lysine-310 regulates the transcriptional activation of NF-κB target genes and contributes to maintaining constitutively active NF-κB in tumors. Bromodomain-containing factor Brd4 has been shown to bind to acetylated lysine-310 and to regulate the transcrip...

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Bibliografiske detaljer
Main Authors: Zou, Zhenhua, Huang, Bo, Wu, Xuewei, Zhang, Houjin, Qi, Jun, Bradner, James, Nair, Satish, Chen, Lin-Feng
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913736/
https://ncbi.nlm.nih.gov/pubmed/23686307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.179
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