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Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-κB
The nuclear function of the heterodimeric NF-κB transcription factor is regulated in part through reversible acetylation of its RelA subunit. We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, 221 and 3...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2002
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC136963/ https://ncbi.nlm.nih.gov/pubmed/12456660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf660 |
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