Molecular Dynamics Simulation Studies of the Wild-Type, I21V, and I16T Mutants of Isoniazid-Resistant Mycobacterium tuberculosis Enoyl Reductase (InhA) in Complex with NADH: Toward the Understanding of NADH-InhA Different Affinities

The increasing prevalence of tuberculosis in many areas of the world, associated with the rise in drug-resistant Mycobacterium tuberculosis (MTB) strains, presents a major threat to global health. InhA, the enoyl-ACP reductase from MTB, catalyzes the nicotinamide adenine dinucleotide (NADH)-dependen...

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Hlavní autoři: Schroeder, Evelyn Koeche, Basso, Luiz Augusto, Santos, Diógenes Santiago, Norberto de Souza, Osmar
Médium: Artigo
Jazyk:Inglês
Vydáno: Biophysical Society 2005
Témata:
Biophysical Theory and Modeling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366637/
https://ncbi.nlm.nih.gov/pubmed/15908576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.053512
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