Conversion of A(3) Adenosine Receptor Agonists into Selective Antagonists by Modification of the 5′-Ribofuran-uronamide Moiety

The highly selective agonists of the A(3) adenosine receptor (AR), Cl-IB-MECA (2-chloro-N(6)-(3-iodobenzyl)-5′-N-methylcarboxamidoadenosine) and its 4′-thio analogue, were successfully converted into selective antagonists simply by appending a second N-methyl group on the 5′-uronamide position. The...

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Auteurs principaux: Gao, Zhan-Guo, Joshi, Bhalchandra V., Klutz, Athena, Kim, Soo-Kyung, Lee, Hyuk Woo, Kim, Hea Ok, Jeong, Lak Shin, Jacobson, Kenneth A.
Format: Artigo
Langue:Inglês
Publié: 2005
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1351218/
https://ncbi.nlm.nih.gov/pubmed/16289820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2005.10.054
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