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Design of (N)-Methanocarba Adenosine 5′-Uronamides as Species-Independent A(3) Receptor-Selective Agonists
2-Chloro-5′ -N-methylcarboxamidoadenosine analogues containing the (N)-methanocarba (bicyclo[3.1.0]hexane) ring system as a ribose substitute display increased selectivity as agonists of the human A(3) adenosine receptor (AR). However, the selectivity in mouse was greatly reduced due to an increased...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2430186/ https://ncbi.nlm.nih.gov/pubmed/18424135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.04.001 |
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