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Design of (N)-Methanocarba Adenosine 5′-Uronamides as Species-Independent A(3) Receptor-Selective Agonists

2-Chloro-5′ -N-methylcarboxamidoadenosine analogues containing the (N)-methanocarba (bicyclo[3.1.0]hexane) ring system as a ribose substitute display increased selectivity as agonists of the human A(3) adenosine receptor (AR). However, the selectivity in mouse was greatly reduced due to an increased...

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Bibliografske podrobnosti
Main Authors: Melman, Artem, Gao, Zhan-Guo, Kumar, Deepmala, Wan, Tina C., Gizewski, Elizabeth, Auchampach, John A., Jacobson, Kenneth A.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430186/
https://ncbi.nlm.nih.gov/pubmed/18424135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.04.001
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