Canine Adenovirus Vectors for Lung-Directed Gene Transfer: Efficacy, Immune Response, and Duration of Transgene Expression Using Helper-Dependent Vectors

A major hurdle to the successful clinical use of some viral vectors relates to the innate, adaptive, and memory immune responses that limit the efficiency and duration of transgene expression. Some of these drawbacks may be circumvented by using vectors derived from nonhuman viruses such as canine a...

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Bibliographic Details
Main Authors: Keriel, Anne, René, Céline, Galer, Chad, Zabner, Joseph, Kremer, Eric J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346928/
https://ncbi.nlm.nih.gov/pubmed/16415025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.3.1487-1496.2006
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