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Host Cell Detection of Noncoding Stuffer DNA Contained in Helper-Dependent Adenovirus Vectors Leads to Epigenetic Repression of Transgene Expression

Helper-dependent adenovirus (hdAd) vectors have shown great promise as therapeutic gene delivery vehicles in gene therapy applications. However, the level and duration of gene expression from hdAd can differ considerably depending on the nature of the noncoding stuffer DNA contained within the vecto...

詳細記述

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書誌詳細
主要な著者: Ross, P. Joel, Kennedy, Michael A., Parks, Robin J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738174/
https://ncbi.nlm.nih.gov/pubmed/19515759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00796-09
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