Helper-Dependent Adenovirus Vectors Elicit Intact Innate but Attenuated Adaptive Host Immune Responses In Vivo

Helper-dependent adenovirus (HD-Ad) vectors with all adenoviral genes deleted mediate very long-term expression of therapeutic transgenes in a variety of animal models of disease. These vectors are associated with reduced toxicity and improved safety relative to traditional early region 1 deletion f...

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Detalhes bibliográficos
Main Authors: Muruve, Daniel A., Cotter, Matthew J., Zaiss, Anne K., White, Lindsay R., Liu, Qiang, Chan, Trevor, Clark, Sharon A., Ross, P. Joel, Meulenbroek, Robert A., Maelandsmo, Gunhild M., Parks, Robin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC415814/
https://ncbi.nlm.nih.gov/pubmed/15140994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.11.5966-5972.2004
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