Differential Activation of Innate Immune Responses by Adenovirus and Adeno-Associated Virus Vectors

Adenovirus vectors induce acute inflammation of infected tissues due to activation of the innate immune system and expression of numerous chemokines and cytokines in transduced target cells. In contrast, adeno-associated virus (AAV) vectors are not associated with significant inflammation experiment...

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Main Authors: Zaiss, Anne-Kathrin, Liu, Qiang, Bowen, Gloria P., Wong, Norman C. W., Bartlett, Jeffrey S., Muruve, Daniel A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC155101/
https://ncbi.nlm.nih.gov/pubmed/11932423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.9.4580-4590.2002
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