Differential Activation of Innate Immune Responses by Adenovirus and Adeno-Associated Virus Vectors

Adenovirus vectors induce acute inflammation of infected tissues due to activation of the innate immune system and expression of numerous chemokines and cytokines in transduced target cells. In contrast, adeno-associated virus (AAV) vectors are not associated with significant inflammation experiment...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zaiss, Anne-Kathrin, Liu, Qiang, Bowen, Gloria P., Wong, Norman C. W., Bartlett, Jeffrey S., Muruve, Daniel A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2002
Schlagworte:
Gene Therapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC155101/
https://ncbi.nlm.nih.gov/pubmed/11932423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.9.4580-4590.2002
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