Assembly of Helper-Dependent Adenovirus DNA into Chromatin Promotes Efficient Gene Expression

Helper-dependent adenovirus (hdAd) vectors have shown tremendous potential in animal models of human disease in numerous preclinical studies. Expression of a therapeutic transgene can be maintained for several years after a single administration of the hdAd vector. However, despite the long-term per...

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Bibliographic Details
Main Authors: Ross, P. Joel, Kennedy, Michael A., Christou, Carin, Risco Quiroz, Milagros, Poulin, Kathy L., Parks, Robin J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126148/
https://ncbi.nlm.nih.gov/pubmed/21307207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01787-10
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