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Canine helper-dependent vectors production: implications of Cre activity and co-infection on adenovirus propagation
The importance of Cre recombinase to minimize helper vector (HV) contamination during helper-dependent adenovirus vectors (HDVs) production is well documented. However, Cre recombinase, by inducing DNA double-strand breaks (DSBs), can cause a reduced proliferation and genotoxic effects in cultured c...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4360735/ https://ncbi.nlm.nih.gov/pubmed/25774853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09135 |
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