Загрузка...

Canine helper-dependent vectors production: implications of Cre activity and co-infection on adenovirus propagation

The importance of Cre recombinase to minimize helper vector (HV) contamination during helper-dependent adenovirus vectors (HDVs) production is well documented. However, Cre recombinase, by inducing DNA double-strand breaks (DSBs), can cause a reduced proliferation and genotoxic effects in cultured c...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Fernandes, Paulo, Almeida, Ana I., Kremer, Eric J., Alves, Paula M., Coroadinha, Ana S.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360735/
https://ncbi.nlm.nih.gov/pubmed/25774853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09135
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!