Novel Gyrase Mutations in Quinolone-Resistant and -Hypersusceptible Clinical Isolates of Mycobacterium tuberculosis: Functional Analysis of Mutant Enzymes

Mutations in the DNA gyrase GyrA(2)GyrB(2) complex are associated with resistance to quinolones in Mycobacterium tuberculosis. As fluoroquinolones are being used increasingly in the treatment of tuberculosis, we characterized several multidrug-resistant clinical isolates of M. tuberculosis carrying...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Aubry, Alexandra, Veziris, Nicolas, Cambau, Emmanuelle, Truffot-Pernot, Chantal, Jarlier, Vincent, Fisher, L. Mark
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2006
Gaiak:
Mechanisms of Resistance
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346799/
https://ncbi.nlm.nih.gov/pubmed/16377674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.104-112.2006
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