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Expression and Purification of an Active Form of the Mycobacterium leprae DNA Gyrase and Its Inhibition by Quinolones

Mycobacterium leprae, the causative agent of leprosy, is noncultivable in vitro; therefore, evaluation of antibiotic activity against M. leprae relies mainly upon the mouse footpad system, which requires at least 12 months before the results become available. We have developed an in vitro assay for...

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Detalhes bibliográficos
Main Authors: Matrat, Stéphanie, Petrella, Stéphanie, Cambau, Emmanuelle, Sougakoff, Wladimir, Jarlier, Vincent, Aubry, Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855561/
https://ncbi.nlm.nih.gov/pubmed/17325221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01282-06
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