Expression and Purification of an Active Form of the Mycobacterium leprae DNA Gyrase and Its Inhibition by Quinolones

Mycobacterium leprae, the causative agent of leprosy, is noncultivable in vitro; therefore, evaluation of antibiotic activity against M. leprae relies mainly upon the mouse footpad system, which requires at least 12 months before the results become available. We have developed an in vitro assay for...

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Hlavní autoři: Matrat, Stéphanie, Petrella, Stéphanie, Cambau, Emmanuelle, Sougakoff, Wladimir, Jarlier, Vincent, Aubry, Alexandra
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2007
Témata:
Susceptibility
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855561/
https://ncbi.nlm.nih.gov/pubmed/17325221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01282-06
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