Novel Gyrase Mutations in Quinolone-Resistant and -Hypersusceptible Clinical Isolates of Mycobacterium tuberculosis: Functional Analysis of Mutant Enzymes

Mutations in the DNA gyrase GyrA(2)GyrB(2) complex are associated with resistance to quinolones in Mycobacterium tuberculosis. As fluoroquinolones are being used increasingly in the treatment of tuberculosis, we characterized several multidrug-resistant clinical isolates of M. tuberculosis carrying...

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Bibliographische Detailangaben
Hauptverfasser: Aubry, Alexandra, Veziris, Nicolas, Cambau, Emmanuelle, Truffot-Pernot, Chantal, Jarlier, Vincent, Fisher, L. Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346799/
https://ncbi.nlm.nih.gov/pubmed/16377674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.1.104-112.2006
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