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Oxygen-Dependent Ubiquitination and Degradation of Hypoxia-Inducible Factor Requires Nuclear-Cytoplasmic Trafficking of the von Hippel-Lindau Tumor Suppressor Protein

It is becoming increasingly evident that the degradation of nuclear proteins requires nuclear-cytoplasmic trafficking of both the substrate proteins, as well as the E3 ubiquitin-ligases. Here, we show that nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein (VHL) is req...

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書目詳細資料
發表在:Mol Cell Biol
Principais autores: Groulx, Isabelle, Lee, Stephen
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2002
主題:
在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133938/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12101228/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.15.5319-5336.2002
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