SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation

SOCS-6 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS-1 to SOCS-7 and CIS) which each contain a central SH2 domain and a carboxyl-terminal SOCS box. SOCS-1, SOCS-2, SOCS-3, and CIS act to negatively regulate cytokine-induced signaling pathways; however, the actio...

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Detalhes bibliográficos
Main Authors: Krebs, Danielle L., Uren, Rachel T., Metcalf, Donald, Rakar, Steven, Zhang, Jian-Guo, Starr, Robyn, De Souza, David P., Hanzinikolas, Kathy, Eyles, Jo, Connolly, Lisa M., Simpson, Richard J., Nicola, Nicos A., Nicholson, Sandra E., Baca, Manuel, Hilton, Douglas J., Alexander, Warren S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133908/
https://ncbi.nlm.nih.gov/pubmed/12052866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4567-4578.2002
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