Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)

Mice with inactivation of the gene encoding the suppressor of cytokine signaling-1 (SOCS-1) die in neonatal life with an IFN-γ-dependent inflammatory disease dominated by fatty degeneration and necrosis of the liver. To establish the long-term pathological consequences of loss of SOCS-1 in mice, whe...

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Bibliographic Details
Main Authors: Metcalf, Donald, Mifsud, Sandra, Di Rago, Ladina, Nicola, Nicos A., Hilton, Douglas J., Alexander, Warren S.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC117410/
https://ncbi.nlm.nih.gov/pubmed/11782537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022628499
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