Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)

Mice with inactivation of the gene encoding the suppressor of cytokine signaling-1 (SOCS-1) die in neonatal life with an IFN-γ-dependent inflammatory disease dominated by fatty degeneration and necrosis of the liver. To establish the long-term pathological consequences of loss of SOCS-1 in mice, whe...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Metcalf, Donald, Mifsud, Sandra, Di Rago, Ladina, Nicola, Nicos A., Hilton, Douglas J., Alexander, Warren S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117410/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782537/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.022628499
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