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Oncogenic ras and p53 Cooperate To Induce Cellular Senescence
Oncogenic activation of the mitogen-activated protein (MAP) kinase cascade in murine fibroblasts initiates a senescence-like cell cycle arrest that depends on the ARF/p53 tumor suppressor pathway. To investigate whether p53 is sufficient to induce senescence, we introduced a conditional murine p53 a...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133786/ https://ncbi.nlm.nih.gov/pubmed/11971980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.10.3497-3508.2002 |
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