Oncogenic ras and p53 Cooperate To Induce Cellular Senescence

Oncogenic activation of the mitogen-activated protein (MAP) kinase cascade in murine fibroblasts initiates a senescence-like cell cycle arrest that depends on the ARF/p53 tumor suppressor pathway. To investigate whether p53 is sufficient to induce senescence, we introduced a conditional murine p53 a...

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Hlavní autoři: Ferbeyre, Gerardo, de Stanchina, Elisa, Lin, Athena W., Querido, Emmanuelle, McCurrach, Mila E., J. Hannon, Gregory, Lowe, Scott W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC133786/
https://ncbi.nlm.nih.gov/pubmed/11971980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.10.3497-3508.2002
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