Oncogenic ras and p53 Cooperate To Induce Cellular Senescence

Oncogenic activation of the mitogen-activated protein (MAP) kinase cascade in murine fibroblasts initiates a senescence-like cell cycle arrest that depends on the ARF/p53 tumor suppressor pathway. To investigate whether p53 is sufficient to induce senescence, we introduced a conditional murine p53 a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Ferbeyre, Gerardo, de Stanchina, Elisa, Lin, Athena W., Querido, Emmanuelle, McCurrach, Mila E., J. Hannon, Gregory, Lowe, Scott W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC133786/
https://ncbi.nlm.nih.gov/pubmed/11971980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.10.3497-3508.2002
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker