Oncogenic ras and p53 Cooperate To Induce Cellular Senescence
Oncogenic activation of the mitogen-activated protein (MAP) kinase cascade in murine fibroblasts initiates a senescence-like cell cycle arrest that depends on the ARF/p53 tumor suppressor pathway. To investigate whether p53 is sufficient to induce senescence, we introduced a conditional murine p53 a...
Gespeichert in:
| Veröffentlicht in: | Mol Cell Biol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11971980/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.10.3497-3508.2002 |
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