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Deletion of the Gene Encoding Proprotein Convertase 5/6 Causes Early Embryonic Lethality in the Mouse

PC5 belongs to the proprotein convertase family and activates precursor proteins by cleavage at basic sites during their transit through the secretory pathway and/or at the cell surface. These precursors include prohormones, proreceptors, growth factors, adhesion molecules, and viral glycoproteins....

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Главные авторы: Essalmani, Rachid, Hamelin, Josée, Marcinkiewicz, Jadwiga, Chamberland, Ann, Mbikay, Majambu, Chrétien, Michel, Seidah, Nabil G., Prat, Annik
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317638/
https://ncbi.nlm.nih.gov/pubmed/16354705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.1.354-361.2006
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