Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice

The Ikaros transcription factor is both a key regulator of lymphocyte differentiation and a tumor suppressor in T lymphocytes. Mice carrying a hypomorphic mutation (Ik(L/L)) in the Ikaros gene all develop thymic lymphomas. Ik(L/L) tumors always exhibit strong activation of the Notch pathway, which i...

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Hauptverfasser: Dumortier, Alexis, Jeannet, Robin, Kirstetter, Peggy, Kleinmann, Eva, Sellars, MacLean, dos Santos, Nuno R., Thibault, Christelle, Barths, Jochen, Ghysdael, Jacques, Punt, Jennifer A., Kastner, Philippe, Chan, Susan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317628/
https://ncbi.nlm.nih.gov/pubmed/16354692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.1.209-220.2006
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